Thionyl Chloride → HCID 23018027, compound

Participants

Reaction Steps

At 0° C., 0.75 mL (10.4 mmol) of thionyl chloride was dropped into a solution of 1.00 g (5.23 mmol) of (8-fluoro-2-methylquinolin-4-yl)methanol obtained in the above 1) in chloroform (12 mL) and stirred for 15 hours at room temperature. The reaction mixture was removed under a reduced pressure and then, the residue was washed with ethyl acetate to obtain 1.29 g (yield 100%) of 4-chloromethyl-8-fluoro-2-methylquinoline hydrochloride (XII-124). Its physical property is shown below.

Provenance & Evidence