4-Amino-3-dimethoxymethyl-benzoic Acid Methyl Ester → Methyl 4-amino-3-formylbenzoate

HRID 1788402Notes

Reaction equation

HRID 1788402 reaction equation
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([CH:11](OC)[O:12]C)[CH:5]=1>CCO.C(O)(=O)C.O>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([CH:11]=[O:12])[CH:5]=1

Participants

3

Reactant 1

HCID 576031164-Amino-3-dimethoxymethyl-benzoic Acid Methyl Ester

Product 1

HCID 46911801Methyl 4-amino-3-formylbenzoate

Reagents, catalysts & solvents 1

HCID 86584229Acetic acid ethanol waterSolvent

Procedure

Compound 6 (0.95 g, 4.2 mmol) was dissolved at room temperature in 15 mL of a solvent mixture composed of EtOH-acetic acid-water 2:2:1. The strongly colored yellow solution became pale yellow in 5 minutes. The mixture was let stand for an additional 15 minutes before it was evaporated to dryness and further dried in high vacuum overnight to get Compound 7 as a yellow powder.

Workup

  1. customfor an additional 15 minutes
  2. customwas evaporated to dryness
  3. customfurther dried in high vacuum overnight

Sources & evidence

ORD record
ord-0f88972134c84ff88bec872e5ace47db
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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