反应详情

Compound 18 (410 mg, 1.75 mmol) and Compound 7 (315 mg, 1.75 mmol) were dissolved in 30 mL of ethanol, 2.45 mL of a 10% KOH/ethanol solution was added and the mixture was refluxed overnight under argon. The ethanol was evaporated, the residue dissolved in water, and acidified with 3 mL of 1M HCl. The formed gel was solidified by addition of 30 mL of ethyl acetate and 30 mL of a saturated NaCl solution. The solid was filtered, awashed with water, and dried. Yield 302 mg (48%) Compound 19.

1. temperaturethe mixture was refluxed overnight under argon
2. customThe ethanol was evaporated
3. dissolutionthe residue dissolved in water
4. additionThe formed gel was solidified by addition of 30 mL of ethyl acetate and 30 mL of a saturated NaCl solution
5. filtrationThe solid was filtered
6. customdried