HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1788414Generated: November 4, 2026
Methanol → 2-[2-Hydroxy-5-(pyrrolidine-1-carbonyl)-phenyl]-quinoline-6-carboxylic Acid Methyl Ester
https://huagongshe.com/reaction/1788414
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-[2-Hydroxy-5-(pyrrolidine-1-carbonyl)-phenyl]-quinoline-6-carboxylic Acid | HCID 136096450 | — |
| Solvent | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | 2-[2-Hydroxy-5-(pyrrolidine-1-carbonyl)-phenyl]-quinoline-6-carboxylic Acid Methyl Ester | HCID 136096449 | — |
Reaction Steps
To the solution of 295 mg (0.81 mmol) of Compound 19 in 3 mL of methanol, 1 mL of 4M HCl/dioxane was added, and the mixture was heated at 60° C. overnight. The reaction mixture was then evaporated to dryness to give Compound 20 in quantitative yield. MS: 377.18 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07511145B2 |
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| Source dataset | uspto-grants-2009_03 |
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| ORD ID | ord-57391e0ab296494086ca597e54799ab9 |
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| Source note | uspto-grants-2009_03 |
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