反应详情

To the solution of Compound 42 (0.95 mmol) in 25 mL ethanol 5 mL, 1 M NaOH was added and the mixture was refluxed for 1 h. It was then cooled and evaporated to dryness. The residue was dissolved in 50 mL water, acidified with 1M HCl to pH 4. The precipitate was filtered off, washed with water (4×) and dried to give 345 mg (81%) of the title compound which maybe further purified by RP-HPLC.

1. temperaturethe mixture was refluxed for 1 h
2. temperatureIt was then cooled
3. customevaporated to dryness
4. dissolutionThe residue was dissolved in 50 mL water
5. filtrationThe precipitate was filtered off
6. washwashed with water (4×)
7. customdried