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(2S,4R)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid → 1-[1-Cyclohexyl-2-(2-phenyl-quinoxalin-6-yl)-1h-benzoimidazole-5-carbonyl]-4-hydroxy-pyrrolidine-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2S,4R)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid | HCID 2756109 | — |
| 反応物 | 3-Cyclohexyl-2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]propanoic acid | HCID 5276167 | — |
| 生成物 | 1-[1-Cyclohexyl-2-(2-phenyl-quinoxalin-6-yl)-1h-benzoimidazole-5-carbonyl]-4-hydroxy-pyrrolidine-2-carboxylic acid | HCID 60029469 | 50% |
反応手順
The general procedure described for Compound 242 was used with Fmoc-Hyp Wang resin (143 mg, 0.7 mmol/g), producing 23 mg of the title compound (50% yield). MS: 560.23 (M−H+) HPLC Procedure A, retention time=11.58 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07511145B2 |
| 出典データセット | uspto-grants-2009_03 |
| ORD ID | ord-5c49fcd2ea8941769c8e93158e59cf9b |
| 出典メモ | uspto-grants-2009_03 |