HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fmoc-L-Tic-OH → 2-[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fmoc-L-Tic-OH | HCID 978341 | — |
| Reactant | 3-Cyclohexyl-2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]propanoic acid | HCID 5276167 | — |
| Product | 2-[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid | HCID 5276199 | 41% |
Reaction Steps
The general procedure described for Compound 242 was used with Fmoc-Tic Wang resin (143 mg, 0.7 mmol/g), producing 25 mg of the title compound (41% yield). MS: 606.22 (M−H+) HPLC Procedure A, retention time=17.18 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511145B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-6f0029f5f5a74f9fb2c53ce9bc2035db |
| Source note | uspto-grants-2009_03 |