3-({2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carbonyl}-amino)-4-cyclohexylamino-benzoic acid ethyl ester → HCID 178524152, compound

HRID 1788436Notes

Reaction equation

HRID 1788436 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]2[C:11]([C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[C:17](C(O)=O)[CH:18]=4)[N:13]=3)=[CH:10][CH:9]=[CH:8][CH:7]=2)=[CH:4][CH:3]=1.C([O:29][C:30](=[O:77])[C:31]1[CH:36]=[CH:35][C:34]([NH:37]C2CCCCC2)=[C:33]([NH:44][C:45](C2C=C3C(=CC=2)N=C(C2C(C4C=CC(Cl)=CC=4)=CC=C(C(N4CCCC4)=O)C=2)C=C3)=O)[CH:32]=1)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]2[C:11]([C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[C:17]([C:45]5[NH:37][C:34]6[CH:35]=[CH:36][C:31]([C:30]([OH:29])=[O:77])=[CH:32][C:33]=6[N:44]=5)[CH:18]=4)[N:13]=3)=[CH:10][CH:9]=[CH:8][CH:7]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 576030893-({2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carbonyl}-amino)-4-cyclohexylamino-benzoic acid ethyl esterHCID 860275072-(4'-Chloro-biphen-2-yl)-quinoline-6-carboxylic acid

Product 1

HCID 178524152HCID 178524152, compound

Procedure

The title compound was synthesized from Compound 353b in two steps as described for Compound 25 and 27 Q=ethyl, respectively.

Sources & evidence

ORD record
ord-4f413cfc3b0141ebacd5e8fccda73064
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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