反应详情

To a solution of 5.49 g (21.5 mmol) of Compound 5 in 200 mL of methanol, 50 mL of 1M NaOH were added and the mixture was stirred at room temperature for 2 h. The reaction mixture was then evaporated to dryness, the residue was dissolved in 100 mL water, acidified with 1 M HCl to pH 3-4. The precipitate was then filtered off, washed with water (4×), and dried. Yield: 4.96 g (95%).

1. customThe reaction mixture was then evaporated to dryness
2. dissolutionthe residue was dissolved in 100 mL water
3. filtrationThe precipitate was then filtered off
4. washwashed with water (4×)
5. customdried