Pyridine → HCID 131727378, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1 g (1.7 mmol) of Compound 475a in 20 mL of DCM, 550 μL (6.8 mmol) of pyridine, and 21 mg (0.17 mmol) of DMAP were added and the entire mixture was cooled to 0° C. Dropwise, 860 μL of Tf2O was added. The reaction was then stirred at room temperature for 1 h. Finally the reaction mixture was evaporated, and the product dissolved in ethyl acetate, washed with cold water (2×), brine (2×), dried with Na2SO4 and evaporated again to give the title intermediate as a white solid foam in quantitative yield.

Provenance & Evidence