Valinamide → HCID 68922125, compound

HRID 1788459Notes

Reaction equation

HRID 1788459 reaction equation
C([O:3][C:4]([C:6]1[CH:38]=[CH:37][C:9]2[N:10]([CH:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[C:18]([C:23](=[O:30])NC(C(=O)N)C)[CH:17]=[CH:16]4)=[N:12][C:8]=2[CH:7]=1)=[O:5])C.[NH2:39][C@H:40]([C:44]([NH2:46])=[O:45])[CH:41]([CH3:43])[CH3:42].C(C(NC(C1C=CC2C(=CC=C(C3N(C4CCCCC4)C4C=CC(C(O)=O)=CC=4N=3)C=2)N=1)=O)C)(=O)N>>[C:44]([CH:40]([NH:39][C:23]([C:18]1[CH:17]=[CH:16][C:15]2[C:20](=[CH:21][CH:22]=[C:13]([C:11]3[N:10]([CH:31]4[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]4)[C:9]4[CH:37]=[CH:38][C:6]([C:4]([OH:5])=[O:3])=[CH:7][C:8]=4[N:12]=3)[CH:14]=2)[N:19]=1)=[O:30])[CH:41]([CH3:43])[CH3:42])(=[O:45])[NH2:46]

Participants

4

Reactant 3

HCID 445637ValinamideHCID 576030502-[2-(1-Carbamoylethylcarbamoyl)quinolin-6-yl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic AcidHCID 689195572-[2-(1-Carbamoylethylcarbamoyl)quinolin-6-yl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic Acid Ethyl Ester

Product 1

HCID 68922125HCID 68922125, compound

Procedure

The title compound (5 mg yield) was prepared as described for Compound 497a using L-valinamide in place of L-alaninamide, and hydrolyzed as described for Compound 497.

Sources & evidence

ORD record
ord-325e96fcb26e4bd99c7218c85a49fa0c
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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