Phenylalanine amide → HCID 68921208, compound

HRID 1788462Notes

Reaction equation

HRID 1788462 reaction equation
C([O:3][C:4]([C:6]1[CH:38]=[CH:37][C:9]2[N:10]([CH:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[C:18]([C:23](=[O:30])[NH:24][CH:25]([C:27](=[O:29])[NH2:28])[CH3:26])[CH:17]=[CH:16]4)=[N:12][C:8]=2[CH:7]=1)=[O:5])C.N[C@H](C(N)=O)C[C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1.C(C(NC(C1C=CC2C(=CC=C(C3N(C4CCCCC4)C4C=CC(C(O)=O)=CC=4N=3)C=2)N=1)=O)C)(=O)N>>[C:27]([CH:25]([NH:24][C:23]([C:18]1[CH:17]=[CH:16][C:15]2[C:20](=[CH:21][CH:22]=[C:13]([C:11]3[N:10]([CH:31]4[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]4)[C:9]4[CH:37]=[CH:38][C:6]([C:4]([OH:3])=[O:5])=[CH:7][C:8]=4[N:12]=3)[CH:14]=2)[N:19]=1)=[O:30])[CH2:26][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)(=[O:29])[NH2:28]

Participants

4

Reactant 3

HCID 445694Phenylalanine amideHCID 576030502-[2-(1-Carbamoylethylcarbamoyl)quinolin-6-yl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic AcidHCID 689195572-[2-(1-Carbamoylethylcarbamoyl)quinolin-6-yl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic Acid Ethyl Ester

Product 1

HCID 68921208HCID 68921208, compound

Procedure

The title compound (5 mg yield) was prepared as described for Compound 497a using L-phenylalaninamide in place of L-alaninamide and hydrolyzed as described for Compound 497.

Sources & evidence

ORD record
ord-f65a74023abf49d7bf98eb90d732f5aa
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

Loading…