4-Chloroaniline → 2-[2-(4-Chlorophenylcarbamoyl)quinolin-6-yl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic Acid Ethyl Ester
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:38]=[CH:37][C:9]2[N:10]([CH:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[C:18]([C:23](=[O:30])[NH:24][CH:25]([C:27](=O)N)[CH3:26])[CH:17]=[CH:16]4)=[N:12][C:8]=2[CH:7]=1)=[O:5])[CH3:2].[Cl:39][C:40]1[CH:46]=CC(N)=C[CH:41]=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:38]=[CH:37][C:9]2[N:10]([CH:31]3[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]3)[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[C:18]([C:23](=[O:30])[NH:24][C:25]3[CH:27]=[CH:46][C:40]([Cl:39])=[CH:41][CH:26]=3)[CH:17]=[CH:16]4)=[N:12][C:8]=2[CH:7]=1)=[O:5])[CH3:2]Participants
3
Procedure
The title compound was prepared as described for Compound 497a using 4-chloroaniline in place of L-alaninamide yielding 91 mg yellow solid. MS: 553.23 (M+H+).
Sources & evidence
- ORD record
- ord-e7621ebc89f2442885f3f2fb8659b267
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07511145B2
Reaction notes
Loading…