2-Bromobenzaldehyde → HCID 12715432, compound

Temperature

-10 °C

A mixture of 2-bromobenzaldehyde (1 mL, 5.4 mmol) in diethylether (2 mL) was added to a flame dried flask, and flushed with argon. The temperature was reduced to −10° C. and benzylmagnesium chloride was slowly added to the flask via syringe. The reaction was stirred at −10° C. for 1 hour and then stirred at room temperature for 16 hours. The reaction was the poured over ice and acidified to pH 3. It was then extracted with ether (3×40 mL). The organic layers were combined, evaporated, and the resulting residue was purified via silica gel chromatography to produce 520 mg (33% yield) of the title intermediate.

1. additionwas added to a flame
2. customdried flask
3. customflushed with argon
4. customwas reduced to −10° C.
5. additionbenzylmagnesium chloride was slowly added to the flask via syringe
6. stirringstirred at room temperature for 16 hours
7. additionpoured over ice
8. extractionIt was then extracted with ether (3×40 mL)
9. customevaporated
10. customthe resulting residue was purified via silica gel chromatography

ORD record

ord-6407c5c47c5d40179ff0ffbe2a0ddb91

Source dataset

uspto-grants-2009_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07511145B2