Cesium fluoride → HCID 5276060, compound

Participants

Reaction Steps

Compound 424 (50 mg, 0.083 mmol), 4-chlorophenylboronic acid (20 mg, 0.125 mmol), and CsF (143 mg, 0.94 mmol) were added to degassed dioxane (6 mL). A solution of 2-(dicyclohexylphosphino)biphenyl (5 mg, 0.0125 mmol) and palladium acetate (2 mg, 0.0083 mmol) in degassed dioxane (3 mL) was added to the reaction solution. The reaction was then refluxed under argon for 3 hours. The reaction was then evaporated to dryness and purified via HPLC resulting in the title compound (4 mg, 10% yield).

Provenance & Evidence