Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Hydroxy-2-pentanone → 1-Cyclohexyl-2-[2-(3-hydroxypropyl)-6-quinolyl]benzimidazole-5-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Hydroxy-2-pentanone | HCID 14066 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 2-[2-(5-Bromo-2-hydroxy-phenyl)-6-quinolyl]-1-cyclohexyl-benzimidazole-5-carboxylic acid | HCID 5275980 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-Cyclohexyl-2-[2-(3-hydroxypropyl)-6-quinolyl]benzimidazole-5-carboxylic acid | HCID 5276015 | 90% |
반응 단계
Following the procedure and workup for Compound 354, Compound 354e (100 mg, 0.256 mmol) was reacted with 5-hydroxy-pentan-2-one (0.256 mmol) in ethanol (2 mL) using 10% w/v KOH in ethanol (506 μL, 0.64 mmol) to produce the title compound (96 mg, 90% yield). MS: 430.23 (M+H+); HPLC Procedure A, retention time=6.84 min, 82.48% purity.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07511145B2 |
| 출처 데이터셋 | uspto-grants-2009_03 |
| ORD ID | ord-d01a71d18ef842d18ec04cd6910db6df |
| 출처 메모 | uspto-grants-2009_03 |