HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Hydroxide → 1-Cyclohexyl-2-[2-[3-(3,4-dichlorophenyl)isoxazol-5-yl]-6-quinolyl]benzimidazole-5-carboxylic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Hydroxide | HCID 14797 | — |
| Edukt | 1-[3-(3,4-Dichlorophenyl)Isoxazol-5-Yl]Ethan-1-One | HCID 2745558 | — |
| Edukt | 2-[2-(5-Bromo-2-hydroxy-phenyl)-6-quinolyl]-1-cyclohexyl-benzimidazole-5-carboxylic acid | HCID 5275980 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 1-Cyclohexyl-2-[2-[3-(3,4-dichlorophenyl)isoxazol-5-yl]-6-quinolyl]benzimidazole-5-carboxylic acid | HCID 5276098 | 15% |
Reaktionsschritte
Following the procedure and workup for Compound 354, Compound 354e (100 mg, 0.256 mmol) was reacted with 1-[3-(3,4-dichloro-phenyl)-isoxazol-5-yl]-ethanone (0.256 mmol) in ethanol (2 mL) using 10% w/v KOH in ethanol (506 μL, 0.64 mmol) to produce the title compound (21 mg, 15% yield). MS: 583.16 (M+H+); HPLC Procedure B, retention time=8.77 min.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07511145B2 |
| Quelldatensatz | uspto-grants-2009_03 |
| ORD ID | ord-670b118e4ab741148e6a2752f946a6b4 |
| Quellennotiz | uspto-grants-2009_03 |