Potassium Hydroxide → HCID 5275989, compound

HRID 1788519Notes

Reaction equation

HRID 1788519 reaction equation
BrC1C=CC(O)=C(C2C=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:18]4[N:22]([CH:23]5[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]5)[C:21]5[CH:29]=[CH:30][C:31]([C:33]([OH:35])=[O:34])=[CH:32][C:20]=5[N:19]=4)[CH:14]=3)[N:9]=2)C=1.[NH2:37][C:38]1[C:43]([Cl:44])=[CH:42][C:41]([C:45](=O)[CH3:46])=[CH:40][C:39]=1[Cl:48].[OH-].[K+]>C(O)C>[NH2:37][C:38]1[C:43]([Cl:44])=[CH:42][C:41]([C:45]2[CH:46]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:18]4[N:22]([CH:23]5[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]5)[C:21]5[CH:29]=[CH:30][C:31]([C:33]([OH:35])=[O:34])=[CH:32][C:20]=5[N:19]=4)[CH:14]=3)[N:9]=2)=[CH:40][C:39]=1[Cl:48]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 6048121-(4-Amino-3,5-dichlorophenyl)ethan-1-oneHCID 52759802-[2-(5-Bromo-2-hydroxy-phenyl)-6-quinolyl]-1-cyclohexyl-benzimidazole-5-carboxylic acid

Product 1

HCID 5275989HCID 5275989, compoundYield 25%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Following the procedure and workup for Compound 354, Compound 354e (100 mg, 0.256 mmol) was reacted with 1-(4-amino-3,5-dichloro-phenyl)-ethanone (0.256 mmol) in ethanol (2 mL) using 10% w/v KOH in ethanol (506 μL, 0.64 mmol) to produce the title compound (31 mg, 25% yield).

Sources & evidence

ORD record
ord-9c192dfdc6f54692b3f47d7b75654ab5
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

Loading…