HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 1-Cyclohexyl-2-[2-(2-hydroxy-5-methyl-3-nitro-phenyl)-6-quinolyl]benzimidazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2'-Hydroxy-5'-methyl-3'-nitroacetophenone | HCID 736162 | — |
| Reactant | 2-[2-(5-Bromo-2-hydroxy-phenyl)-6-quinolyl]-1-cyclohexyl-benzimidazole-5-carboxylic acid | HCID 5275980 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Cyclohexyl-2-[2-(2-hydroxy-5-methyl-3-nitro-phenyl)-6-quinolyl]benzimidazole-5-carboxylic acid | HCID 5276038 | 31% |
Reaction Steps
Following the procedure and workup for Compound 354, Compound 354e (100 mg, 0.256 mmol) was reacted with 1-(2-hydroxy-5-methyl-3-nitro-phenyl)-ethanone (0.256 mmol) in ethanol (2 mL) using 10% w/v KOH in ethanol (506 μL, 0.64 mmol) to produce the title compound (40 mg, 31% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511145B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-fb25cede22a5439ebe3be42255bb5afb |
| Source note | uspto-grants-2009_03 |