HCID 5275992, compound → HCID 5276057, compound

HRID 1788537Notes

Reaction equation

ClC1C=C(C=CC=1F)C1C(C2C=CC3C(=CC=C(C4N(C5CCCCC5)[C:24]5[CH:32]=[CH:33][C:34]([C:36]([OH:38])=[O:37])=[CH:35][C:23]=5N=4)C=3)N=2)=CC(OC)=CC=1.C[O:46][C:47]([C:49]1[CH:82]=[CH:81][C:52]2[N:53]([CH:75]3[CH2:80][CH2:79][CH2:78][CH2:77][CH2:76]3)[C:54]([C:56]3[CH:57]=[C:58]4[C:63](=[CH:64][CH:65]=3)[N:62]=[C:61]([C:66]3[CH:71]=[C:70]([O:72][CH3:73])[CH:69]=[CH:68][C:67]=3Br)[CH:60]=[CH:59]4)=[N:55][C:51]=2[CH:50]=1)=[O:48]>>[C:36]([C:34]1[CH:33]=[C:32]([CH:24]=[CH:23][CH:35]=1)[C:67]1[C:66]([C:61]2[CH:60]=[CH:59][C:58]3[C:63](=[CH:64][CH:65]=[C:56]([C:54]4[N:53]([CH:75]5[CH2:76][CH2:77][CH2:78][CH2:79][CH2:80]5)[C:52]5[CH:81]=[CH:82][C:49]([C:47]([OH:46])=[O:48])=[CH:50][C:51]=5[N:55]=4)[CH:57]=3)[N:62]=2)=[CH:71][C:70]([O:72][CH3:73])=[CH:69][CH:68]=1)([OH:38])=[O:37]

Participants

Reactant 2

HCID 5275992HCID 5275992, compound

HCID 68922215HCID 68922215, compound

Product 1

HCID 5276057HCID 5276057, compoundYield 23%

Procedure

Following the full procedure and workup for Compound 366, Compound 365b (100 mg, 0.175 mmol) was reacted with ethyl 3-boronic acid benzoate (51 mg, 0.2625 mmol) to produce the title compound (26 mg, 23% yield).

Sources & evidence

ORD record: ord-2723f4bee31647beb62e1df971549d8e
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07511145B2

Reaction notes

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