HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2,4-Dimethoxypyrimidin-5-yl)boronic acid → 1-Cyclohexyl-2-[2-[2-(2,4-dimethoxypyrimidin-5-yl)-5-methoxy-phenyl]-6-quinolyl]benzimidazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2,4-Dimethoxypyrimidin-5-yl)boronic acid | HCID 2736209 | — |
| Reactant | HCID 5275992 | HCID 5275992 | — |
| Reactant | HCID 68922215 | HCID 68922215 | — |
| Product | 1-Cyclohexyl-2-[2-[2-(2,4-dimethoxypyrimidin-5-yl)-5-methoxy-phenyl]-6-quinolyl]benzimidazole-5-carboxylic acid | HCID 5276103 | 7% |
Reaction Steps
Following the full procedure and workup for Compound 366, Compound 365b (100 mg, 0.175 mmol) was reacted with 2,4-dimethoxypyrimidine-5-boronic acid (34 mg, 0.2625 mmol) to produce the title compound (8 mg, 7% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511145B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-39fad7e43001435c9baa4847ee94145c |
| Source note | uspto-grants-2009_03 |