Potassium Hydroxide → 2-(4'-Chloro-4-methoxy-biphen-2-yl)-quinoline-6-carboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	Potassium Hydroxide	HCID 14797	—
Reactant	Methyl 4-amino-3-formylbenzoate	HCID 46911801	—
Reactant	2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carboxylic acid	HCID 57602987	—
Solvent	Ethanol	HCID 702	—
Product	2-(4'-Chloro-4-methoxy-biphen-2-yl)-quinoline-6-carboxylic acid	HCID 86027313	91%

Reaction Steps

Compound 7 (3.06 g. 11.72 mmol) was reacted with compound 525a (2.1 g, 11.72 mmol) and KOH (2.32 g, 35.16 mmol) in EtOH (150 mL) according to the procedure in the preparation of Compound 259e. Purification by chromatography using CHCl3-MeOH (7:1) as the eluent gave the title intermediate (3.1 g, 91%). MS: 388.07 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07511145B2
Source dataset	uspto-grants-2009_03
ORD ID	ord-8cc70d6dc4db4e4f9f8dc74e63e90d69
Source note	uspto-grants-2009_03