HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → Benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 2-(4'-Chloro-4-methoxy-biphen-2-yl)-quinoline-6-carboxylic acid | HCID 86027313 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Benzimidazole | HCID 5798 | — |
Reaction Steps
Compound 525c (0.38 g, 0.97 mmol) was reacted with HBTU (0.444 g, 1.2 mmol) in anhydrous DMF (5 mL) in the presence of DIEA (0.41 mL, 2.35 mmol) for 30 min. The mixture was then transferred to a suspension of amine-resin in DMF (5 mL). The reaction mixture was shaken at room temperature overnight. The solution was drained and the resin was washed with DMF (5 mL×5), MeOH (5 mL×5), and CH2Cl2 (5 mL×5). The resin was dried under high vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511145B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-2267f3d53bda4933bade31f83b91eb23 |
| Source note | uspto-grants-2009_03 |