4-Chloro-3-nitrobenzoic acid → 2-[2-[2-(4-Chlorophenyl)-5-methoxy-phenyl]-6-quinolyl]-1-cyclopropyl-benzimidazole-5-carboxylic acid
Reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-])=O.C1(N)CC1.[Cl:18][C:19]1[CH:56]=[CH:55][C:22]([C:23]2[C:28]([C:29]3[CH:38]=[CH:37][C:36]4[C:31](=[CH:32][CH:33]=[C:34]([C:39]5N(CC)C6C=C[C:48](C(O)=O)=[CH:49][C:41]=6[N:40]=5)[CH:35]=4)[N:30]=3)=[CH:27][C:26]([O:53][CH3:54])=[CH:25][CH:24]=2)=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([C:23]2[C:28]([C:29]3[CH:38]=[CH:37][C:36]4[C:31](=[CH:32][CH:33]=[C:34]([C:39]5[N:40]([CH:41]6[CH2:49][CH2:48]6)[C:2]6[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=6[N:11]=5)[CH:35]=4)[N:30]=3)=[CH:27][C:26]([O:53][CH3:54])=[CH:25][CH:24]=2)=[CH:55][CH:56]=1Participants
4
Reactant 3
Product 1
Procedure
The title compound was prepared from Resin 534a and cyclopropylamine according to the procedure described in the preparation of Compound 534.
Sources & evidence
- ORD record
- ord-2af721953d1e433ba339919acca129b0
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07511145B2
Reaction notes
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