HRID1788575

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID258030

n-chloroaniline

C6H6ClN

反应SMILES：CN(C)c1cc(-c2ccccc2)nc2ccc(-c3nc4cc(C(=O)O)ccc4n3C3CCCCC3)cc12

HCID5276100

未命名化合物

反应SMILES：CCOC(=O)c1ccc2c(c1)nc(-c1ccc3nc(-c4ccccc4)cc(Cl)c3c1)n2C1CCCCC1

HCID68924249

未命名化合物

PRODUCTS

产物

反应SMILES：O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4ccccc4)cc(Nc4ccc(Cl)cc4)c3c1)n2C1CCCCC1

HCID5276004

未命名化合物

PROCEDURE

实验过程

The title compound was prepared using the method described for Compound 481. In this reaction 102 mg (0.2 mmol) of crude 2-(4-chloro-2-phenyl-quinolin-6-yl)-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid ethyl ester were used. The nucleophile used wasp-chlorophenylamine. Yield: 89 mg.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-36172fd882c8461fabaa669a99e3754e
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07511145B2
来源说明: uspto-grants-2009_03

反应SMILES

[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:20]=[C:21]3[C:26](=[CH:27][CH:28]=2)[N:25]=[C:24]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:23]=[C:22]3[N:35](C)[CH3:36])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(OC(C1C=CC2N(C3CCCCC3)C(C3[CH:51]=[C:52]4C(=CC=3)N=[C:55](C3C=CC=CC=3)[CH:54]=[C:53]4[Cl:66])=NC=2C=1)=O)C.ClNC1C=CC=CC=1>>[Cl:66][C:53]1[CH:54]=[CH:55][C:36]([NH:35][C:22]2[C:21]3[C:26](=[CH:27][CH:28]=[C:19]([C:8]4[N:7]([CH:1]5[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]5)[C:11]5[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:10]=5[N:9]=4)[CH:20]=3)[N:25]=[C:24]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH:23]=2)=[CH:51][CH:52]=1