4-Amino-1-butanol → HCID 11410057, compound

HRID 1788576Notes

Reaction equation

HRID 1788576 reaction equation
C([O:3][C:4]([C:6]1C=CC2N(C3CCCCC3)C(C3C=C4C(=CC=3)N=C(C3C=CC=CC=3)C=C4Cl)=NC=2[CH:7]=1)=O)C.[CH:38]1([N:44]2[C:48]3[CH:49]=[CH:50][C:51]([C:53]([OH:55])=[O:54])=[CH:52][C:47]=3[N:46]=[C:45]2[C:56]2[CH:57]=[C:58]3[C:63](=[CH:64][CH:65]=2)[N:62]=[C:61]([C:66]2[CH:71]=[CH:70][CH:69]=[CH:68][CH:67]=2)[CH:60]=[C:59]3[N:72]([CH3:74])C)[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1.NCCCCO>>[CH:38]1([N:44]2[C:48]3[CH:49]=[CH:50][C:51]([C:53]([OH:55])=[O:54])=[CH:52][C:47]=3[N:46]=[C:45]2[C:56]2[CH:57]=[C:58]3[C:63](=[CH:64][CH:65]=2)[N:62]=[C:61]([C:66]2[CH:67]=[CH:68][CH:69]=[CH:70][CH:71]=2)[CH:60]=[C:59]3[NH:72][CH2:74][CH2:7][CH2:6][CH2:4][OH:3])[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1

Participants

4

Reactant 3

HCID 258684-Amino-1-butanolHCID 52761001-Cyclohexyl-2-[4-(dimethylamino)-2-phenyl-6-quinolyl]benzimidazole-5-carboxylic acidHCID 68924249HCID 68924249, compound

Product 1

HCID 11410057HCID 11410057, compound

Procedure

In this reaction 102 mg (0.2 mmol) of crude 2-(4-chloro-2-phenyl-quinolin-6-yl)-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid ethyl ester were used in the same reaction sequence as that used for Compound 481. The nucleophile used was 4-amino-butan-1-ol. Yield: 59 mg.

Sources & evidence

ORD record
ord-66afaa298b0647eda13e4be36dd69ac2
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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