HRID1788580

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7969

Benzenethiol

C6H6S

反应SMILES：CN(C)c1cc(-c2ccccc2)nc2ccc(-c3nc4cc(C(=O)O)ccc4n3C3CCCCC3)cc12

HCID5276100

未命名化合物

反应SMILES：CCOC(=O)c1ccc2c(c1)nc(-c1ccc3nc(-c4ccccc4)cc(Cl)c3c1)n2C1CCCCC1

HCID68924249

未命名化合物

PRODUCTS

产物

反应SMILES：O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4ccccc4)cc(Sc4ccccc4)c3c1)n2C1CCCCC1

HCID5276086

未命名化合物

PROCEDURE

实验过程

In this reaction 51 mg (0.1 mmol) of crude 2-(4-chloro-2-phenyl-quinolin-6-yl)-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid ethyl ester were used in the same reaction sequence as that used for Compound 481. The nucleophile used was benzenethiol. Yield: 36 mg.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-aa14fd58b6d1427a9dc5fa7265be2ca5
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07511145B2
来源说明: uspto-grants-2009_03

反应SMILES

C([O:3][C:4]([C:6]1[CH:37]=[CH:36][C:9]2[N:10]([CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[C:18]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:17]=[C:16]4Cl)=[N:12][C:8]=2[CH:7]=1)=[O:5])C.C1(N2C3C=CC(C(O)=O)=CC=3N=C2C2C=C3C(=CC=2)N=C(C2C=CC=CC=2)C=C3N(C)C)CCCCC1.[C:75]1([SH:81])[CH:80]=[CH:79][CH:78]=[CH:77][CH:76]=1>>[CH:30]1([N:10]2[C:9]3[CH:36]=[CH:37][C:6]([C:4]([OH:3])=[O:5])=[CH:7][C:8]=3[N:12]=[C:11]2[C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]=[C:18]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:17]=[C:16]3[S:81][C:75]2[CH:80]=[CH:79][CH:78]=[CH:77][CH:76]=2)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1