Thiophenol → HCID 5276086, compound

HRID 1788580Notes

Reaction equation

HRID 1788580 reaction equation
C([O:3][C:4]([C:6]1[CH:37]=[CH:36][C:9]2[N:10]([CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[C:18]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:17]=[C:16]4Cl)=[N:12][C:8]=2[CH:7]=1)=[O:5])C.C1(N2C3C=CC(C(O)=O)=CC=3N=C2C2C=C3C(=CC=2)N=C(C2C=CC=CC=2)C=C3N(C)C)CCCCC1.[C:75]1([SH:81])[CH:80]=[CH:79][CH:78]=[CH:77][CH:76]=1>>[CH:30]1([N:10]2[C:9]3[CH:36]=[CH:37][C:6]([C:4]([OH:3])=[O:5])=[CH:7][C:8]=3[N:12]=[C:11]2[C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]=[C:18]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:17]=[C:16]3[S:81][C:75]2[CH:80]=[CH:79][CH:78]=[CH:77][CH:76]=2)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1

Participants

4

Reactant 3

HCID 7969ThiophenolHCID 52761001-Cyclohexyl-2-[4-(dimethylamino)-2-phenyl-6-quinolyl]benzimidazole-5-carboxylic acidHCID 68924249HCID 68924249, compound

Product 1

HCID 5276086HCID 5276086, compound

Procedure

In this reaction 51 mg (0.1 mmol) of crude 2-(4-chloro-2-phenyl-quinolin-6-yl)-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid ethyl ester were used in the same reaction sequence as that used for Compound 481. The nucleophile used was benzenethiol. Yield: 36 mg.

Sources & evidence

ORD record
ord-aa14fd58b6d1427a9dc5fa7265be2ca5
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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