HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1788582Generated: November 3, 2026
Hydrochloric Acid → 1-Cyclohexyl-2-[2-(4-quinolyl)-6-quinolyl]benzimidazole-5-carboxylic acid
https://huagongshe.com/reaction/1788582
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-(Quinolin-4-yl)ethan-1-one | HCID 12340190 | — |
| Reactant | 2-(4-amino-3-formyl-phenyl)-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid ethyl ester | HCID 86600382 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Cyclohexyl-2-[2-(4-quinolyl)-6-quinolyl]benzimidazole-5-carboxylic acid | HCID 5276043 | 19.3% |
Reaction Steps
(1-Quinolin-4-yl-ethanone (43 mg, 0.25 mmol) and 2-(4-amino-3-formyl-phenyl)-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid ethyl ester (98 mg, 0.25 mmol) were dissolved in 500 μL ethanol and 500 μL 10% ethanolic KOH were then added. The reaction was stirred at 75° C. overnight. The reaction was acidified with 4N hydrochloric acid, extracted three times with ethyl acetate, and the organic extracts were dried with sodium sulfate and then evaporated. Purification via reverse-phase HPLC gave 24 mg product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07511145B2 |
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| Source dataset | uspto-grants-2009_03 |
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| ORD ID | ord-4019479c4c134858b9dfdacc9546d653 |
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| Source note | uspto-grants-2009_03 |
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