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2-{2-[(4-Chlorophenyl)methyl carbamoyl]quinolin-6-yl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic Acid Ethyl Ester → 2-{2-[(4-Chlorophenyl)methyl carbamoyl]quinolin-6-yl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-{2-[(4-Chlorophenyl)methyl carbamoyl]quinolin-6-yl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic Acid Ethyl Ester | HCID 68922365 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 2-{2-[(4-Chlorophenyl)methyl carbamoyl]quinolin-6-yl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic Acid | HCID 21158127 | 10.1% |
反応手順
A solution of 63 mg (0.11 mmol) of Compound 546c in 0.55 mL THF, 0.44 mL of EtOH and 0.11 mL of 2 N aq. NaOH was allowed to stand at room temperature overnight. The reaction was quenched with 0.22 mL 1 M aq. HCl. The solvents were removed and the residue was purified by HPLC to yield 6 mg of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07511145B2 |
| 出典データセット | uspto-grants-2009_03 |
| ORD ID | ord-e28513a172e944558539493e46709591 |
| 出典メモ | uspto-grants-2009_03 |