4-chloro-N-cyclohexylaniline → 2-{2-[(4-Chlorophenyl)cyclohexyl carbamoyl]quinolin-6-yl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic Acid Ethyl Ester

HRID 1788594노트

반응식

HRID 1788594 반응식
[CH2:1]([O:3][C:4]([C:6]1[CH:41]=[CH:40][C:9]2[N:10]([CH:34]3[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]3)[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[C:18]([C:23](=[O:33])NCC3C=CC(Cl)=CC=3)[CH:17]=[CH:16]4)=[N:12][C:8]=2[CH:7]=1)=[O:5])[CH3:2].[Cl:42][C:43]1[CH:48]=[CH:47][C:46]([NH:49][CH:50]2[CH2:55][CH2:54][CH2:53][CH2:52][CH2:51]2)=[CH:45][CH:44]=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:41]=[CH:40][C:9]2[N:10]([CH:34]3[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]3)[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[C:18]([C:23](=[O:33])[N:49]([C:46]3[CH:45]=[CH:44][C:43]([Cl:42])=[CH:48][CH:47]=3)[CH:50]3[CH2:55][CH2:54][CH2:53][CH2:52][CH2:51]3)[CH:17]=[CH:16]4)=[N:12][C:8]=2[CH:7]=1)=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 112758174-chloro-N-cyclohexylanilineHCID 689223652-{2-[(4-Chlorophenyl)methyl carbamoyl]quinolin-6-yl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic Acid Ethyl Ester

생성물 1

HCID 689285522-{2-[(4-Chlorophenyl)cyclohexyl carbamoyl]quinolin-6-yl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic Acid Ethyl Ester

실험 절차

The title compound was prepared as described for Compound 546c using Compound 546b in place of 4-chloro-N-methylaniline. MS: 635.31 (M+H+).

출처 및 근거

ORD 기록
ord-e51b810aaa854df5bdc71ee4878dfb71
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511145B2

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