4-Fluorophenylboronic acid → HCID 131727380, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 200 mg (0.29 mmol) Compound 419d 62 mg (0.44 mmol) 4-fluorophenyl-boronic acid, 32 mg (0.029 mmol) Pd(PPh3)4 and 2 mL sat. NaHCO3 in 16 mL degassed MeOH was heated at 90° C. under Ar overnight. The mixture was evaporated to dryness, the residue was taken up in CH2Cl2 and purified on silica gel using CH2Cl21MeOH as eluent to yield 197 mg orange solid.

Provenance & Evidence