Hydrochloric Acid → 2-[2-[2-(4-Chlorophenyl)-5-fluoro-phenyl]-6-quinolyl]-1-cyclohexyl-benzimidazole-5-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

1-(4′-Chloro-4-fluoro-biphen-2-yl)-ethanone (62 mg, 0.25 mmol) and 2-(4-amino-3-formyl-phenyl)-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid ethyl ester (98 mg, 0.25 mmol) were dissolved in 500 μL ethanol and 500 μL 10% ethanolic KOH were added. The reaction was stirred at 75° C. overnight. The reaction was acidified with 4N hydrochloric acid, extracted three times with ethyl acetate, the organic extracts were dried with sodium sulfate and then evaporated. Purification via reverse-phase HPLC gave 84 mg product.

Provenance & Evidence