Hydrochloric Acid → 2-[2-[8-(4-chlorophenyl)-3,4-dihydro-2H-1,5-benzodioxepin-7-yl]-6-quinolyl]-1-cyclohexyl-benzimidazole-5-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

1-[8-(4-Chloro-phenyl)-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl]-ethanone (76 mg, 0.25 mmol) and 2-(4-amino-3-formyl-phenyl)-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid ethyl ester (98 mg, 0.25 mmol) were dissolved in 500 μL ethanol and 500 μL 10% ethanolic KOH were added. The reaction was stirred at 75° C. overnight. The reaction was acidified with 4N hydrochloric acid, extracted three times with ethyl acetate, the organic extracts were dried with sodium sulfate and then evaporated. Purification via reverse-phase HPLC gave 132 mg of the title compound.

Provenance & Evidence