N-BOC-ethylenediamine → HCID 11307974, compound

HRID 1788609Notes

Reaction equation

HRID 1788609 reaction equation
C([O:3][C:4]([C:6]1[CH:37]=[CH:36][C:9]2[N:10]([CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[C:18]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:17]=[C:16]4Cl)=[N:12][C:8]=2[CH:7]=1)=[O:5])C.[C:38]([O:42][C:43](=[O:48])[NH:44][CH2:45][CH2:46][NH2:47])([CH3:41])([CH3:40])[CH3:39]>>[C:38]([O:42][C:43]([NH:44][CH2:45][CH2:46][NH:47][C:16]1[C:15]2[C:20](=[CH:21][CH:22]=[C:13]([C:11]3[N:10]([CH:30]4[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]4)[C:9]4[CH:36]=[CH:37][C:6]([C:4]([OH:5])=[O:3])=[CH:7][C:8]=4[N:12]=3)[CH:14]=2)[N:19]=[C:18]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:17]=1)=[O:48])([CH3:41])([CH3:39])[CH3:40]

Participants

3

Reactant 2

HCID 187201N-BOC-ethylenediamineHCID 68924249HCID 68924249, compound

Product 1

HCID 11307974HCID 11307974, compound

Procedure

In this reaction 51 mg (0.1 mmol) of crude 2-(4-chloro-2-phenyl-quinolin-6-yl)-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid ethyl ester were used. The nucleophile used was (2-amino-ethyl)-carbamic acid tert-butyl ester. Yield: 21 mg.

Sources & evidence

ORD record
ord-0ba2bb4cec354b52a5f09a1610b62ab4
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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