Isobutylamine → HCID 178449184, compound

Participants

Reaction Steps

A solution of 12.3 g of N-cyano-N'-(1,2,3,4-tetrahydro-1-naphthyl)-S-methylisothiourea and 20 ml of isobutylamine in 100 ml of acetonitrile was heated at reflux with stirring for 100 hours. The solvent was then removed by evaporation in vacuo. The residual oil was dissolved in methylene chloride and the solution was washed with three 80 ml portions of 3N hydrochloric acid and then dried over anhydrous sodium sulfate. The sodium sulfate was removed by filtration, and the methylene chloride was removed from the filtrate by evaporation in vacuo, leaving N"-cyano-N-isobutyl-N'-(1,2,3,4-tetrahydro-1-naphthyl)guanidine as 11.6 g of a pale yellow, viscous oil.

Provenance & Evidence