Glycol monoethyl ether → HCID 178447880, compound

Participants

Reaction Steps

2-Ethoxyethanol (200 ml), water (40 ml) and zinc powder (20 g) were added to 2-(trans-4-n-propylcyclohexyl)-5-cyano-6-chloropyridine (17.0 g) of Example 6, followed by heating the mixture under reflux for 28 hours, cooling, thereafter filtering, adding toluene (200 ml) and water (500 ml) to the filtrate, stirring, still standing, separating the toluene layer, twice washing it with water, and carrying out the same procedure as in Example 11 to obtain the objective 2-(trans-4- n-propylcyclohexyl)-5-cyanopyridine (5 g). C-N point: 47.6° C. N-I point: 51.9° C.

Provenance & Evidence