Hydrochloric Acid → HCID 13912590, compound

Participants

Reaction Conditions

Reaction Steps

To ethyl 6,7-difluoro-1-(4 -methoxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate (0.61 g) are added 90% acetic acid (8.0 ml) and conc. hydrochloric acid (2.0 ml), and the mixture is heated with stirring at 110° C. for 2 hours. After the reaction, the solvent is distilled off under reduced pressure. The resulting residue is washed well with water to give 6,7-difluoro-1-(4-methoxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.54 g) as colorless needles, m.p. 256°-258° C.

Provenance & Evidence