P-Anisidine → HCID 23359023, compound

Participants

Reaction Steps

A mixture of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-ethoxyacrylate (0.4 g), p-anisidine (0.15 g) and ethanol (4 ml) is stirred at room temperature for 30 minutes. After the reaction, the solvent is distilled off under reduced pressure. To the resulting residue is added anhydrous dioxane (10 ml) and further added portionwise 60% sodium hydride (60 mg). The mixture is stirred at room temperature for 30 minutes. Thereafter, the reaction mixture is poured into saturated aqueous ammonium chloride and then extracted with dichloromethane to give ethyl 6,7,8-trifluoro-1-(4-methoxyphenyl)- 1,4-dihydro-4-oxoquinoline-3-carboxylate (0.37 g).

Provenance & Evidence