Hydrochloric Acid → HCID 13912594, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 6,7,8-trifluoro-1-(4-methoxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate (0.37 g), conc. hydrochloric acid (1 ml) and 90% acetic acid (4 ml) is heated at 120° C. for one hour. After cooling, the precipitated crystals are separated by filtration, washed well with water and with a mixture of ethanol and ether to give 6,7,8-trifluoro-1-(4-methoxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.3 g) as white crystals, m.p. 252°-254° C.

Provenance & Evidence