Hydrogen Bromide → HCID 13912595, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 6,7,8-trifluro-1-(4-methoxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate (0.37 g) and 47% hydrobromic acid (4 ml) is heated at 120° C. for 3 hours. After cooling, the precipitated crystals are separated by filtration, washed with water and further with a mixture of ethanol and ether to give 6,7,8-trifluoro-1-(4-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.26 g), m.p. >300° C., white crystals.

Provenance & Evidence