Dimethylformamide → HCID 131715225, compound

Participants

Reaction Steps

A mixture of trans-4-[3-(4-fluorophenyl)-6-fluoro-indan-1-yl]-1-piperazineethanol (40 g, 0.11 mol), thionylchloride (15 ml) and DMF (0.7 ml) in methylene chloride (400 ml) was refluxed for 1 hour. After cooling, the crystalline solid was filtered and washed on the filter with ethyl acetate and ether to give trans 1-[3-(4-fluorophenyl)-indan-1-yl]-4-(2-chloroethyl)piperazine, dihydrochloride (45 g). Mp: 250°-255° C.

Provenance & Evidence