Water → HCID 86741690, compound

Participants

Reaction Conditions

Reaction Steps

To 5-(4-chlorobutyryl)-1,3-benzodioxole (4.0 g) and N-phenylpiperazine (3.0 g) dissolved in DMF (25 ml) was added triethylamine (2.2 g) and the mixture was heated at 80° C. for 40 hours under stirring. After completion of the reaction, the reaction mixture was poured into water and extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate and the solvent was distilled off. The residue was dissolved in ethyl acetate and 20% hydrogen chloride in ethanol (6.5 ml) was added. The resulting crystals were collected by filtration and recrystallized from ethanol to give 5-[4-phenyl-1-piperazinyl)butyryl]-1,3-benzodioxole dihydrochloride (5.1 g, 68% yield). The characteristics of this compound are shown in Table 3 as Compound 57.

Provenance & Evidence