Sodium Hydroxide → HCID 13139730, compound

Participants

Reaction Steps

5-[4-(4-Phenyl-1-piperazinyl)butyryl]-1,3-benzodioxole dichloride (3.8 g) as prepared in Example 2 was suspended in methanol (50 ml) and 2N sodium hydroxide solution (4.5 ml) and then sodium borohydride (0.5 g) were added. The mixture was stirred for 10 hours at room temperature and the solvent was then distilled off. The residue was extracted with ethyl acetate and the extract was washed with saturated saline and dried over anhydrous sodium sulfate. Thereafter, 20% hydrogen chloride in ethanol (4.9 ml) was added and the resulting crystals were collected by filtration and recrystallized from ethanol to give 5-[4-(4-phenyl-1-piperazinyl)-1-hydroxybutyl]-1,3-benzodioxole dihydrochloride (3.5 g, 62% yield). The characteristics of this compound are shown in Table 3 as Compound 19.

Provenance & Evidence