HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron trifluoride etherate → (2alpha,5alpha,17beta)-2-(Diethoxymethyl)-17-methoxyandrostan-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 17beta-Methoxy-5alpha-androstan-3-one | HCID 11044935 | — |
| Product | (2alpha,5alpha,17beta)-2-(Diethoxymethyl)-17-methoxyandrostan-3-one | HCID 54489025 | 117.7% |
Reaction Steps
By the method of part A of Example 20 (5α,17β)-17-methoxyandrostan-3-one (45.67 g., 0.15 mole) was diethoxymethylated using triethylorthoformate (55.0 ml., 49.0 g., 0.33 mole) and boron trifluoride etherate (50.0 ml., 57.7 g., 0.407 mole), affording (2α,5α,17β)-2-(diethoxymethyl)-17-methoxyandrostan-3-one (71.81 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04684636 |
| Source dataset | uspto-grants-1987_08 |
| ORD ID | ord-2b1b0fd95f8c46db929f42c1c3e98c4e |
| Source note | uspto-grants-1987_08 |