Imidazole → HCID 20190090, compound

Participants

Reaction Steps

A solution of 1-(2-hydroxyethyl)-2-oxoimidazolidine (13 g) in dimethylformamide (50 ml) containing imidazole (7.5 g) was treated with t-butylchlorodiphenylsilane (28.6 ml) and the clear solution stirred for 3 hours at ambient temperature. The white suspension formed was dissolved in water (200 ml) and ethyl acetate (500 ml). The aqueous phase was re-extracted with ethyl acetate (100 ml) and the combined organic phases were washed with 3×100 ml portions of water, 1×100 ml brine, dried and evaporated to give a solid. Trituration of the solid with diethyl ether (100 ml) afforded the title compound as a white solid, (33.7 g).

Provenance & Evidence