反应详情

温度

90 °C

A mixture of 2.93 g of isatoic anhydride, 2.50 g of 1H-imidazole-propanamine and 30 ml of toluene was heated at 90° C. for 45 minutes and cooled. The toluene layer was decanted and the residue was dissolved in methylene chloride, washed with dilute sodium hydroxide solution, water and dried over magnesium sulfate. The organic layer was concentrated to obtain the desired product, mp 107°-110° C.

1. temperaturecooled
2. customThe toluene layer was decanted
3. dissolutionthe residue was dissolved in methylene chloride
4. washwashed with dilute sodium hydroxide solution, water
5. dry with materialdried over magnesium sulfate
6. concentrationThe organic layer was concentrated