HCID 13956780, compound → HCID 20190358, compound

HRID 1788687Notes

Reaction equation

HRID 1788687 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][N:10]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([N+:21]([O-])=O)[CH:17]=3)[NH:12][C:11]2=[O:24])[CH:5]=[CH:4][N:3]=[CH:2]1.[H][H]>[Pd].C(O)C>[NH2:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:24])[N:10]([CH2:9][CH2:8][CH2:7][CH2:6][N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1)[C:19]2=[O:20]

Participants

5

Reactant 2

HCID 13956780HCID 13956780, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20190358HCID 20190358, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 2.0 g of 3-[4-(1H-imidazol-1-yl)butyl]-6-nitro-2,4(1H,3H)-quinazolinedione, 1.0 g of 10% palladium-on-carbon catalyst and 200 ml of ethanol is shaken in a Parr hydrogenater under 45 pounds of hydrogen pressure until the hydrogen uptake is complete. The reaction mixture is heated to the boil and the catalyst is filtered off. The ethanolic solution is concentrated to a low volume and the desired product is recovered by filtration.

Workup

  1. temperatureThe reaction mixture is heated to the boil
  2. filtrationthe catalyst is filtered off
  3. concentrationThe ethanolic solution is concentrated to a low volume
  4. filtrationthe desired product is recovered by filtration

Sources & evidence

ORD record
ord-05763b91920d467bbcbc6ee6a79c82e2
Source dataset
uspto-grants-1987_08
Patent number
US04684654

Reaction notes

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