Ethanethiol → HCID 13912578, compound

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Reaction Steps

A solution of 0.80 g (0.0014 mole) of 1-(Butylsulfonyl)-1, 6-dihydro-2-[[(4-methoxyphenyl) methyl]thio]-4-methyl-6-(3-nitrophenyl)-5-pyrimidinecarboxylic acid, ethyl ester, 0.52 ml (0.0057 mole) of trifluoroacetic acid and 0.21 g (0.0032 mole) of ethanethiol in 15 ml of dichloromethane was stirred at room temperature for 24 hours. The solvent was evaporated, and the residue was flash chromatographed using ethyl acetate/ hexane (1:4) to give an oil which solidified very slowly. Trituration with isopropyl ether gave 0.33 g of the title compound as a colorless solid, melting point 118°-120° C. Analysis Calc'd. for C18H23N3O6S2 : C, 48.96; H, 5.25; N, 9.51; S, 14.52. Found: C, 48.99; H, 5.42; N, 9.32; S, 14.48.

Provenance & Evidence