反应详情

温度

0 °C

2-Phenylquinoline-4-carboxylic acid chloride hydrochloride (10.7 g) is added in portions over a period of 1 hour to a stirred solution of N,N-dimethylamine (18.9 g) in methylene chloride (100 ml), cooled to 0° C. The mixture is stirred for 1 hour at 0° C. The solution is evaporated under reduced pressure. The residue is taken up in methylene chloride (100 ml). The organic phase is washed with water (3×100 ml), dried over magnesium sulphate and evaporated under reduced pressure.

1. customThe solution is evaporated under reduced pressure
2. washThe organic phase is washed with water (3×100 ml)
3. dry with materialdried over magnesium sulphate
4. customevaporated under reduced pressure