N-Methyl-2-butanamine → N-methyl-N-(1-methylpropyl)-2-phenylquinoline-4-carboxamide

HRID 1788736Notes

Reaction equation

HRID 1788736 reaction equation
Cl.[C:2]1([C:8]2[CH:17]=[C:16]([C:18](Cl)=[O:19])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:21][NH:22][CH:23]([CH2:25][CH3:26])[CH3:24]>C(Cl)Cl>[CH3:21][N:22]([CH:23]([CH3:24])[CH2:25][CH3:26])[C:18]([C:16]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:17]=1)=[O:19]

Participants

4

Reactant 2

HCID 111026N-Methyl-2-butanamineHCID 123740002-Phenylquinoline-4-carbonyl chloride hydrochloride

Product 1

HCID 13336354N-methyl-N-(1-methylpropyl)-2-phenylquinoline-4-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The procedure of Example 42 is followed using 2-phenylquinoline-4-carboxylic acid chloride hydrochloride (10.7 g) and N-methylbut-2-ylamine (10.5 g) in methylene chloride (75 ml) as the starting materials.

Sources & evidence

ORD record
ord-a8d870d60c46421f8f40204640049401
Source dataset
uspto-grants-1987_08
Patent number
US04684652

Reaction notes

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